David M. Mosser

Professor

Research Interests: Innate and Adaptive Immunity to Microbial Pathogens.

Mosser Lab Homepage

The Maryland Pathogen Research Institute (MPRI)

The plasticity of macrophages allows them to change their physiology in responses to changes in their microenvironment.  Our laboratory is interested in exploiting the plasticity of these remarkable cells to i) enhance immunity, ii) prevent autoimmunity, or iii) promote wound healing and tissue regeneration.  We employ a variety of experimental approaches in Immunology and Cell Biology to understand the molecular mechanisms by which macrophages can change their physiology and mediate these divergent processes.

Studies on host defense to infectious diseases focus on: I) the cell and molecular biology of macrophage infection by intracellular pathogens. II) The molecules produced by macrophages that mediate the killing of intracellular pathogens. III) An analysis of monocyte or macrophage subsets during inflammatory and infectious diseases.

Studies relating to the host inflammatory response focus on: I) the regulation of cytokine gene expression in macrophages and dendritic cells. II) receptor-mediated modulation of cytokine production. III) the development of novel anti-inflammatory therapeutics to treat autoimmune diseases.

Recent Publications

Zhang, X. and Mosser, D.M.  2008.  Macrophage activation by endogenous danger signals.  J. Pathol. 214:161-78.

Bonfield, T.L., Thomassen, M.J., Farver, C.F., Abraham, S. Koloze, M.T., Zhang, X., Mosser, D.M. and Culver, D.A. 2008.  J. Immunology 181:235-42.

Zhang, X. Goncalves, R. and Mosser, D.M. 2008. The isolation and characterization of murine macrophages. Current Protocols Immunology. Unit 14.1

Mosser, D.M. and Zhang, X. 2008. Activation of murine macrophages.  Current Protocols Immunology. Unit 14.2

Mosser, D.M. and Zhang, X. 2008.  IL-10: New perspectives on an old cytokine.  Immunological Reviews. 226:205-218

Mosser, D.M. and Edwards, J. P. 2008.  Exploring the full spectrum of macrophage activation.  Nature Reviews Immunology. 8:958-969.

Marbach-Ad, G. Briken, V., El-Sayed, N., Frauwirth, K. Fredericksen, B., Hutcheson, S., Gao, L., Joseph, S., Lee, V., McIver, K. S., Mosser, D. M., Quimby, B. B., Shields, P. Song, W. Stein, D. C., Yuan, R. T. and Smith, A. C.  2009. Assessing Student Understanding of Host Pathogen Interactions Using a Concept Inventory. J. Microbiol. Biol. Edu. 10:43-50.

Cates, E.A., Connor, E.E., Mosser, D.M. and Bannerman, D.D. 2009.  Functional characterization of bovine TIRAP and MyD88 in mediating bacterial lipopolysaccharide-induced endothelial NF-kB activation and apoptosis. Comp. Immunol. Microbiol. Infect. Dis. 32:477-90.

Edwards, J.P. Zhang, X. and Mosser, D.M. 2009.  The expression of heparin-binding epidermal growth factor-like growth factor by regulatory macrophages.  J. Immunology 182:1929-39.

Zhang, X. Edwards, J.P. and Mosser, D.M. 2009. The expression of exogenous genes in macrophages: obstacles and opportunities. Methods in Mol. Biol.  531:123-43.

Gallo, P. Goncalves, R. and Mosser, D.M. 2010.  The influence of IgG Density on Phagocytosis and IL-10 Production following Macrophage Fc (gamma) Receptor Cross-linking.  Immunol Letters 133:70-7.

Halstead, S.A. Mahalingham, S. Marovich, M. A. Ubol, S. and Mosser, D.M.  2010.  Intrinsic antibody enhancement of infection in macrophages: disease regulation by immune complexes.  Lancet Infect. Dis. 10:712-22.

Marbach-Ad G. McAdams, K.C. Benson, S. Briken, V. Cathcart, L. Chase, M. El-Sayed, N. Frauwirth, K. Fredericksen, B. Joseph, S. Lee, V. McIver, K. Mosser, D.M. Quimby, B.B. Shields, P. Song, W. Stein, D.C. Stewart, R. Thompson, K.V. Smith, A.C. 2010. A model for using a concept inventory as a tool for students’ assessment and faculty professional development. CBE Life Sci Educ. 9:408-16.

Reis M.L. Ferreira, V.M. Zhang, X. Goncalves, R. Vieira L.Q. Tafuri, W.L. Mosser, D.M. and Tafuri, W.L. 2010. Murine immune responses induced by Leishmania major during the implantation of paraffin tablets.  Virchows Arch. 457:609-18.

Yang, Z. Zhang, X. Darrah, P.A. and Mosser, D.M. 2010. The regulation of Th1 responses by the p38 MAPK. J. Immunol. 185:6205-13.

Liu, X. Lu, L. Yang, Z. Palaniyandi, S. Zeng, R. Gao, L.Y. Mosser, D.M. Roopenian, D.C. and Zhu, X. 2011.  The neonatal FcR mediated presentation of immune complexed antigen in associated with endosomal and phagosomal pH and antigan stability in macrophages and dendritic cells.  J. Immunol. 186:4674-86.

Yang, Z. Kong, B. Mosser, D.M. and Zhang, X. 2011.  TLRs, macrophages and NK cells: Our understanding of their function in the uterous and ovary. Int. Immunopharmacol. 11:1442-50.

Goncalves, R. Zhang, X. Cohen, H. Debrabant, A. and Mosser, D.M. 2011.  Platelet activation attracts a subpopulation of effector monocytes to sites of L. major infection.  J. Exp. Med. 208:1253-65.

Fleming,B.D. and Mosser, D.M. 2011 Regulatory macrophages:  Setting the threshold for therapy.  Eur. J. Immunol.  41:2498-502.

Briken, V. and Mosser, D.M. 2011.  Switching on arginase in M2 macrophages.  J. Leuk. Biol. 90:839-41.

Mosser, D.M. and Zhang, X.  2011. Measuring opsonic phagocytosis via Fcγ receptors and complement receptors on macrophages.  Curr. Protoc. Immunol. XChapter 14, Unit 14.27

Previous Graduate Students (year of Ph.D. and present position)

Mary K. Hondalus, 1995, Associate Professor (tenured), University of Georgia

Dona C. Love, 1996, Staff Scientist, National Institutes of Health, Bethesda, MD

Andrew Brittingham, 1998, Associate Professor (tenured), Des Moines University, School of Osteopathic Medicine, Des Moines, IA

Fayyaz Sutterwala (MD/PhD student), 1999, Assistant Professor, University of Iowa Medical School. Iowa City, IA

Margaret Mentink Kane, 2001, Staff Scientist, National Institutes of Health, Bethesda, MD

Gang Chen, 2001, Group Leader, Astra Zenica, Wilmington, DE

Patricia A. Darrah, 2001, Staff Scientist, National Institutes of Health, Bethesda, MD

Jeffrey Gerber (MD/PhD student), 2001, Assistant Professor, Children's Hospital of Pennsylvania, Philadelphia, PA

Charles F. Anderson, 2002, Staff Scientist, Sanaria, Rockville, MD

Suzanne A. Miles, 2005, Site Manager, Lancaster Laboratories, West Point, PA

Sean Conrad, 2006, Law offices of K & L Gates, Pittsburgh, PA

Anne E. Field, 2007, Project Manager, MedImmune, Rockville, MD.

Justin P. Edwards, 2008, Postdoctoral fellow, National Institutes of Health, Bethesda, MD

Ziyan Yang, 2009, Physician, Dept Obstetrics and Gynecology, Shandong University, China

Previous Undergraduate Students

Paul Gallo, Temple University Medical School, MD/PhD Program

Sagie Wagage, University of Pennsylvania, Graduate Student

Vic Prasanna, Pittsburgh University Medical School, Resident

Eric Stickles, Temple University Medical School, Resident

Current lab members

Ricardo Gonclaves, Postdoctoral fellow
Bryan Fleming, Graduate Student
Rahul Suresh, Graduate Student
Heather Cohen, Graduate student
Amanda Ward, Undergraduate Student
Ramsey Bekdash, Undergraduate Student