David Mosser

Innate and Adaptive Immunity to Pathogens.

Macrophages and dendritic cells occupy a unique niche in the immune system. These cells participate in host defense to infectious microorganisms, and mediate potentially deleterious host inflammatory responses. A variety of experimental approaches in Immunology and Cell Biology have begun to reveal the molecular mechanisms by which these cell can mediate these two divergent processes.

Studies on host defense to infectious diseases focus on: I) the cell and molecular biology of macrophage infection by intracellular pathogens. II) The molecules produced by macrophages that mediate the killing of intracellular pathogens. III) An analysis of monocyte or macrophage subsets during inflammatory and infectious diseases

Studies relating to the host inflammatory response focus on: I) the regulation of cytokine gene expression in macrophages and dendritic cells. II) receptor-mediated modulation of cytokine production. III) the development of novel anti-inflammatory therapeutics to treat autoimmune diseases.

2009

Edwards, J.P. Zhang, X. and Mosser, D.M. 2009. The expression of HB-EGF by regulatory macrophages. J. Immunology 182:1929-39.

2008

Zhang, X. and Mosser, D.M. 2008. Macrophage activation by endogenous danger signals. J. Pathol. 214:161-78.

Mosser, D.M. and Zhang, X. 2008. IL-10: New perspectives on an old cytokine. Immunol Reviews. 226:205-218.

Mosser, D.M. and Edwards, J. P. 2008. Exploring the full spectrum of macrophage activation. Nature Reviews Immunology. 8:958-969.

2007

Conrad, S.M, Strauss-Ayali, D., Field, A.E., Mack, M. and Mosser, D.M. 2007. Leishmania-derived murine Monocyte Chemoattractant Protein 1 enhances the recruitment of a restrictive population of CC chemokines receptor 2-positive macrophages. Infection and Immunity. 75:653-65.

Yang, Z., Mosser, D.M., and Zhang, X. 2007. Activation of the MAPK, ERK following Leishmania amazonensis infection of macrophages. J. Immunology. 178:1077-85.

Zhang, X., Edwards, J.P., and Mosser, D.M. 2007. The expression of exogenous genes in macrophages: obstacles and opportunities. Methods in Molecular Biology Human Press, Ed. N.E. Reiner (in press).

Strauss-Ayali, D., Conrad, S.M. and Mosser, D.M. 2007. Monocyte subpopulations and their differentiation patterns during infection. J. Leukocyte Biol. 82:244-52.

Field, A.E., Wagage, S., Conrad, S.M, and Mosser, D.M. 2007. Reduced pathology following infection with transgenic Leishmania major expressing murine CD40 ligand. Infection and Immunity. 75:3140-49.