Vincent Lee

BSCI412 Microbial Genetics

Host-pathogen interactions, Molecular mechanisms of pathogenesis for Pseudomonas aeruginosa, Allosteric regulation of molecular complexes.

Kulasakara, H., Lee, V., Brencic, A., Liberati, N., Urbach, J., Miyata, S., Lee, D.G., Neely, A.N., Hyodo, M., Hayakawa, Y., Ausubel, F.M., and Lory, S. 2006 Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence. Proc Natl Acad Sci U S A. 103:2839-44. Lee, V.T., Pukatzki, S., Sato, H., Kikawada, E., Kazimirova, A.A., Huang, J., Li, X., Arm, J.P., Frank, D.W., and Lory, S. 2007. Pseudolipasin A Is a Specific Inhibitor for Phospholipase A2 Activity of Pseudomonas aeruginosa Cytotoxin ExoU. Infect. Immun. 75: 1089-98. Merighi, M., Lee, V.T., Hyodo, M., Hayakawa, Y., and Lory, S. 2007. The second messenger bis-(3’-5’)-cyclic-GMP and its PilZ domain-containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa. Mol. Microbiol. 65: 876–895. Lee, V.T., Matewish, J.M., Kessler, J.L. Hyodo, M., Hayakawa, Y., and Lory, S. 2007. A Cyclic-di-GMP Receptor Required for Bacterial Exopolysaccharide Production. Mol. Microbiol. 65: 1474-1484. Arnoldo, A., Curak, J., Kittanakom, S., Chevelev, I., Lee, V.T., Sahebol-Amri, M., Koscik, B., Ljuma, L., Roy, P.J., Bedalov, A., Nislow, C., Merrill, R.A., Lory, S. and Stagljar, I. 2007. Identification of small molecule inhibitors of Pseudomonas aeruginosa Exotoxin S using a yeast phenotypic screen. PLoS Genetics. 2:e1000005. Salzberg, S., Sommer, D.D., Puiu, D., and Lee, V.T. 2008. Gene-boosted assembly of a novel bacterial genome from very short reads. PLoS Computational Biology. 4:e1000186.

Ph.D. - University of California - Los Angeles, 2000